A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding
We describe a method to design dominant-negative proteins (D-N) to the basic helix–loop–helix–leucine zipper (B-HLHZip) family of sequence-specific DNA binding transcription factors. The D-Ns specifically heterodimerize with the B-HLHZip dimerization domain of the transcription factors and abolish D...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1997
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24905/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9356439/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.23.12274 |
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