A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding

We describe a method to design dominant-negative proteins (D-N) to the basic helix–loop–helix–leucine zipper (B-HLHZip) family of sequence-specific DNA binding transcription factors. The D-Ns specifically heterodimerize with the B-HLHZip dimerization domain of the transcription factors and abolish D...

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Main Authors: Krylov, Dmitry, Kasai, Kenji, Echlin, Deborah R., Taparowsky, Elizabeth J., Arnheiter, Heinz, Vinson, Charles
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences of the USA 1997
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC24905/
https://ncbi.nlm.nih.gov/pubmed/9356439
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