A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding

We describe a method to design dominant-negative proteins (D-N) to the basic helix–loop–helix–leucine zipper (B-HLHZip) family of sequence-specific DNA binding transcription factors. The D-Ns specifically heterodimerize with the B-HLHZip dimerization domain of the transcription factors and abolish D...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Krylov, Dmitry, Kasai, Kenji, Echlin, Deborah R., Taparowsky, Elizabeth J., Arnheiter, Heinz, Vinson, Charles
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24905/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9356439/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.23.12274
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