Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function.

The reverse transcriptase enzymes of retroviruses are multifunctional proteins containing both DNA polymerase activity and a nuclease activity, termed RNase H, specific for RNA in RNA-DNA hybrid form. To determine the role of RNase H activity in retroviral replication, we constructed a series of mut...

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Pubblicato in:	J Virol
Autori principali:	Tanese, N, Telesnitsky, A, Goff, S P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248878/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1712862/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.8.4387-4397.1991
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