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Ubc4/5 and c-Cbl Continue to Ubiquitinate EGF Receptor after Internalization to Facilitate Polyubiquitination and Degradation

c-Cbl is the E3 ubiquitin ligase that ubiquitinates the epidermal growth factor (EGF) receptor (EGFR). On the basis of localization, knockdown, and in vitro activity analyses, we have identified the E2 ubiquitin-conjugating enzyme that cooperates with c-Cbl as Ubc4/5. Upon EGF stimulation, both Ubc4...

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Detalhes bibliográficos
Main Authors: Umebayashi, Kyohei, Stenmark, Harald, Yoshimori, Tamotsu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2488299/
https://ncbi.nlm.nih.gov/pubmed/18508924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-10-0988
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