Endoplasmic Reticulum Stress-Induced Activation of Activating Transcription Factor 6 Decreases Insulin Gene Expression via Up-Regulation of Orphan Nuclear Receptor Small Heterodimer Partner

The highly developed endoplasmic reticulum (ER) structure of pancreatic β-cells is a key factor in β-cell function. Here we examined whether ER stress-induced activation of activating transcription factor (ATF)-6 impairs insulin gene expression via up-regulation of the orphan nuclear receptor small...

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Main Authors: Seo, Hye-Young, Kim, Yong Deuk, Lee, Kyeong-Min, Min, Ae-Kyung, Kim, Mi-Kyung, Kim, Hye-Soon, Won, Kyu-Chang, Park, Joong-Yeol, Lee, Ki-Up, Choi, Hueng-Sik, Park, Keun-Gyu, Lee, In-Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2488228/
https://ncbi.nlm.nih.gov/pubmed/18450959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0015
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