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Effect of Trimethoprim on Macromolecular Synthesis in Escherichia coli

Trimethoprim is a specific inhibitor of dihydrofolate reductase. When added to amino acid supplemented cultures of Escherichia coli, protein, ribonucleic acid (RNA), and deoxyribonucleic acid synthesis are rapidly inhibited. It is shown that thymidylate and purine synthesis must continuously occur i...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:J Bacteriol
Ngā kaituhi matua: Miovic, Margaret, Pizer, Lewis I.
Hōputu: Artigo
Reo:Inglês
I whakaputaina: American Society for Microbiology (ASM) 1971
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4254117/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.106.3.856-862.1971
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