Effect of Trimethoprim on Macromolecular Synthesis in Escherichia coli
Trimethoprim is a specific inhibitor of dihydrofolate reductase. When added to amino acid supplemented cultures of Escherichia coli, protein, ribonucleic acid (RNA), and deoxyribonucleic acid synthesis are rapidly inhibited. It is shown that thymidylate and purine synthesis must continuously occur i...
Enregistré dans:
| Publié dans: | J Bacteriol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1971
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4254117/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.106.3.856-862.1971 |
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