The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

The target of rapamycin (TOR), as part of the rapamycin-sensitive TOR complex 1 (TORC1), regulates various aspects of protein synthesis. Whether TOR functions in this process as part of TORC2 remains to be elucidated. Here, we demonstrate that mTOR, SIN1 and rictor, components of mammalian (m)TORC2,...

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Hlavní autoři: Facchinetti, Valeria, Ouyang, Weiming, Wei, Hua, Soto, Nelyn, Lazorchak, Adam, Gould, Christine, Lowry, Carolyn, Newton, Alexandra C, Mao, Yuxin, Miao, Robert Q, Sessa, William C, Qin, Jun, Zhang, Pumin, Su, Bing, Jacinto, Estela
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2486276/
https://ncbi.nlm.nih.gov/pubmed/18566586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.120
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