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Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells
In breast cancer cells, cytoplasmic localization of the estradiol receptor α (ERα) regulates estradiol-dependent S phase entry. We identified a nuclear export sequence (NES) in ERα and show that its export is dependent on both estradiol-mediated phosphatidylinositol-3-kinase (PI3K)/AKT activation an...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2483513/ https://ncbi.nlm.nih.gov/pubmed/18644889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200712125 |
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