Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells

In breast cancer cells, cytoplasmic localization of the estradiol receptor α (ERα) regulates estradiol-dependent S phase entry. We identified a nuclear export sequence (NES) in ERα and show that its export is dependent on both estradiol-mediated phosphatidylinositol-3-kinase (PI3K)/AKT activation an...

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Autores principales: Lombardi, Maria, Castoria, Gabriella, Migliaccio, Antimo, Barone, Maria Vittoria, Di Stasio, Rosina, Ciociola, Alessandra, Bottero, Daniela, Yamaguchi, Hiroshi, Appella, Ettore, Auricchio, Ferdinando
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2008
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483513/
https://ncbi.nlm.nih.gov/pubmed/18644889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200712125
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