The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke

BACKGROUND: Macrophage elastase (MMP-12) is involved in the inflammatory process of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate in mice the effect of MMP-12 inhibition on the inflammatory process induced by cigarette smoke (CS) or by lipopolysaccharide (LPS...

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Detalhes bibliográficos
Main Authors: Le Quément, C, Guénon, I, Gillon, J-Y, Valença, S, Cayron-Elizondo, V, Lagente, V, Boichot, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483400/
https://ncbi.nlm.nih.gov/pubmed/18493250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.180
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