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The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading

ERp57 is an oxidoreductase that, in conjunction with calnexin and calreticulin, assists disulfide bond formation in folding glycoproteins. ERp57 also forms a mixed disulfide with the MHC class I-specific chaperone tapasin, and this dimeric conjugate edits the peptide repertoire bound by MHC class I...

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Sonraí Bibleagrafaíochta
Main Authors: Peaper, David R., Cresswell, Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483232/
https://ncbi.nlm.nih.gov/pubmed/18650385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805044105
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