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Insights into MHC class I peptide loading from the structure of the tapasin/ERp57 heterodimer
Tapasin is a glycoprotein critical for loading Major Histocompatibility Complex (MHC) class I molecules with high affinity peptides. It functions within the multimeric peptide-loading complex (PLC) as a disulfide-linked, stable heterodimer with the thiol oxidoreductase ERp57, and this covalent inter...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650231/ https://ncbi.nlm.nih.gov/pubmed/19119025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.10.018 |
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