Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

Phosphoinositide 3-kinase (PI3K) negatively regulates Toll-like receptor (TLR)–mediated interleukin-12 (IL-12) expression in dendritic cells (DCs). We show here that 2 signaling pathways downstream of PI3K, mammalian target of rapamycin (mTOR) and glycogen synthase kinase 3 (GSK3), differentially re...

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Detalhes bibliográficos
Main Authors: Ohtani, Masashi, Nagai, Shigenori, Kondo, Shuhei, Mizuno, Shinta, Nakamura, Kozue, Tanabe, Masanobu, Takeuchi, Tsutomu, Matsuda, Satoshi, Koyasu, Shigeo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481549/
https://ncbi.nlm.nih.gov/pubmed/18492954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-137430
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