Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway

We identified an antigen recognized on a human non-small-cell lung carcinoma by a cytotoxic T lymphocyte clone derived from autologous tumor-infiltrating lymphocytes. The antigenic peptide is presented by HLA-A2 and is encoded by the CALCA gene, which codes for calcitonin and for the α-calcitonin ge...

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Detalhes bibliográficos
Main Authors: El Hage, Faten, Stroobant, Vincent, Vergnon, Isabelle, Baurain, Jean-François, Echchakir, Hamid, Lazar, Vladimir, Chouaib, Salem, Coulie, Pierre G., Mami-Chouaib, Fathia
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481335/
https://ncbi.nlm.nih.gov/pubmed/18626012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802753105
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