Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution

We have previously identified an antigen (Ag) recognized on a human large cell carcinoma of the lung by a tumor-specific cytotoxic T lymphocyte clone derived from autologous tumor infiltrating lymphocytes (TILs). The antigenic peptide is presented by HLA-A2 molecules and is encoded by a mutated α-ac...

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Autores principales: Echchakir, Hamid, Dorothée, Guillaume, Vergnon, Isabelle, Menez, Jeanne, Chouaib, Salem, Mami-Chouaib, Fathia
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC123145/
https://ncbi.nlm.nih.gov/pubmed/12093915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.142308199
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