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A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice
Telomeres are nucleoprotein structures that cap the ends of chromosomes, protecting them from exonucleases and distinguishing them from double-stranded breaks. Their integrity is maintained by telomerase, an enzyme consisting of a reverse transcriptase, TERT and an RNA template, TERC, and other comp...
Wedi'i Gadw mewn:
| Prif Awduron: | , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
National Academy of Sciences
2008
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481326/ https://ncbi.nlm.nih.gov/pubmed/18626023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803559105 |
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