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The central unit within the 19S regulatory particle of the proteasome

The 26S proteasome is a multisubunit enzyme composed of a cylindrical catalytic core (20S) and a regulatory particle (19S) that together perform the essential degradation of cellular proteins tagged by ubiquitin. To date, however, substrate trajectory within the complex remains elusive. Here we desc...

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Autors principals: Rosenzweig, Rina, Osmulski, Pawel A, Gaczynska, Maria, Glickman, Michael H
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481239/
https://ncbi.nlm.nih.gov/pubmed/18511945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1427
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