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Total Synthesis of Ningalin D

A concise (9 step) and effective (19% overall yield) total synthesis of ningalin D (1a) is disclosed and is based on a key 1,2,4,5-tetrazine → 1,2-diazine → pyrrole Diels–Alder strategy to assemble a fully substituted pyrrole core central to its structure. Additional highlights of the synthesis incl...

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Bibliografiska uppgifter
Huvudupphovsmän: Hamasaki, Akiyuki, Zimpleman, Jeffrey M., Hwang, Inkyu, Boger, Dale L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2005
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2480523/
https://ncbi.nlm.nih.gov/pubmed/16045367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0526416
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