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Total Synthesis of Kopsinine

[Image: see text] The use of a powerful intramolecular [4 + 2]/[3 + 2] cycloaddition cascade of an 1,3,4-oxadiazole in the divergent total synthesis of kopsinine (1), featuring an additional unique SmI(2)-promoted transannular cyclization reaction for formation of the bicyclo[2.2.2]octane central to...

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Autors principals: Xie, Jian, Wolfe, Amanda L., Boger, Dale L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578506/
https://ncbi.nlm.nih.gov/pubmed/23391149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol303573f
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