Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

We quantified the amount of amyloid β-peptide (Aβ) immunoreactivity as well as amyloid deposits in a large cohort of transgenic mice overexpressing the V717F human amyloid precursor protein (APP(V717F+/−) TG mice) with no, one, or two mouse apolipoprotein E (Apoe) alleles at various ages. Remarkably...

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Autori principali: Bales, Kelly R., Verina, Tatyana, Cummins, David J., Du, Yansheng, Dodel, Richard C., Saura, Josep, Fishman, Cindy E., DeLong, Cynthia A., Piccardo, Pedro, Petegnief, Valerie, Ghetti, Bernardino, Paul, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1999
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC24803/
https://ncbi.nlm.nih.gov/pubmed/10611368
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