A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model.

We have determined the virulence characteristics of seven monoclonal antibody escape mutants of tick-borne encephalitis virus in the mouse model. One of the mutants with an amino acid substitution from tyrosine to histidine at residue 384 revealed strongly reduced pathogenicity after peripheral inoc...

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Vydáno v:	J Virol
Hlavní autoři:	Holzmann, H, Heinz, F X, Mandl, C W, Guirakhoo, F, Kunz, C
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1990
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2398538/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.10.5156-5159.1990
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