A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model.
We have determined the virulence characteristics of seven monoclonal antibody escape mutants of tick-borne encephalitis virus in the mouse model. One of the mutants with an amino acid substitution from tyrosine to histidine at residue 384 revealed strongly reduced pathogenicity after peripheral inoc...
Enregistré dans:
| Publié dans: | J Virol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1990
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2398538/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.10.5156-5159.1990 |
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