A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model.

We have determined the virulence characteristics of seven monoclonal antibody escape mutants of tick-borne encephalitis virus in the mouse model. One of the mutants with an amino acid substitution from tyrosine to histidine at residue 384 revealed strongly reduced pathogenicity after peripheral inoc...

ver descrição completa

Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Holzmann, H, Heinz, F X, Mandl, C W, Guirakhoo, F, Kunz, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2398538/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.10.5156-5159.1990
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!