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A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model.

We have determined the virulence characteristics of seven monoclonal antibody escape mutants of tick-borne encephalitis virus in the mouse model. One of the mutants with an amino acid substitution from tyrosine to histidine at residue 384 revealed strongly reduced pathogenicity after peripheral inoc...

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Bibliografiske detaljer
Main Authors: Holzmann, H, Heinz, F X, Mandl, C W, Guirakhoo, F, Kunz, C
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC248008/
https://ncbi.nlm.nih.gov/pubmed/2398538
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