Transforming Growth Factor-β Stimulates Intestinal Epithelial Focal Adhesion Kinase Synthesis via Smad- and p38-Dependent Mechanisms

Focal adhesion kinase (FAK) regulates cell migration, proliferation, and apoptosis. FAK protein is reduced at the edge of migrating gut epithelial sheets in vitro, but it has not been characterized in restitutive gut mucosa in vivo. Here we show that FAK and activated phospho-FAK (FAK(397)) immunore...

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Detalhes bibliográficos
Main Authors: Walsh, Mary F., Ampasala, Dinakar R., Hatfield, James, Vander Heide, Richard, Suer, Silke, Rishi, Arun K., Basson, Marc D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475776/
https://ncbi.nlm.nih.gov/pubmed/18583311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070729
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