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β-Arrestin Scaffolding of Phosphatidylinositol 4-Phosphate 5-Kinase Iα Promotes Agonist-stimulated Sequestration of the β2-Adrenergic Receptor

Members of the seven-transmembrane receptor (7TMR) superfamily are sequestered from the plasma membrane following stimulation both to limit cellular responses as well as to initiate novel G protein-independent signaling pathways. The best studied mechanism for 7TMR internalization is via clathrin-co...

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Detalhes bibliográficos
Main Authors: Nelson, Christopher D., Kovacs, Jeffery J., Nobles, Kelly N., Whalen, Erin J., Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475702/
https://ncbi.nlm.nih.gov/pubmed/18534983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800431200
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