Antagonism between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus

At the imprinted Rasgrf1 locus in mouse, a cis-acting sequence controls DNA methylation at a differentially methylated domain (DMD). While characterizing epigenetic marks over the DMD, we observed that DNA and H3K27 trimethylation are mutually exclusive, with DNA and H3K27 methylation limited to the...

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Bibliographic Details
Main Authors: Lindroth, Anders M., Park, Yoon Jung, McLean, Chelsea M., Dokshin, Gregoriy A., Persson, Jenna M., Herman, Herry, Pasini, Diego, Miró, Xavier, Donohoe, Mary E., Lee, Jeannie T., Helin, Kristian, Soloway, Paul D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475503/
https://ncbi.nlm.nih.gov/pubmed/18670629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000145
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