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High dose folic acid pre-treatment blunts cardiac dysfunction during ischemia coupled to maintenance of high energy phosphates and reduces post-reperfusion injury
BACKGROUND: The B-vitamin folic acid (FA) is important to mitochondrial protein and nucleic acid synthesis, is an anti-oxidant, and enhances nitric oxide synthase activity. Here, we tested whether FA reduces myocardial ischemic dysfunction and post-reperfusion injury. METHODS: Wistar rats were pretr...
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Главные авторы: | , , , , , , , , , , , , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
2008
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474781/ https://ncbi.nlm.nih.gov/pubmed/18362233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.725481 |
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