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High dose folic acid pre-treatment blunts cardiac dysfunction during ischemia coupled to maintenance of high energy phosphates and reduces post-reperfusion injury

BACKGROUND: The B-vitamin folic acid (FA) is important to mitochondrial protein and nucleic acid synthesis, is an anti-oxidant, and enhances nitric oxide synthase activity. Here, we tested whether FA reduces myocardial ischemic dysfunction and post-reperfusion injury. METHODS: Wistar rats were pretr...

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Библиографические подробности
Главные авторы: Moens, An L., Champion, Hunter C., Claeys, Marc J., Tavazzi, Barbara, Kaminki, Pawel M., Wolin, Michael S., Borgonjon, Dirk, Van Nassauw, Luc, Haile, Azeb, Zviman, Muz, Bedja, Djahida, Wuyts, Floris L., Elsaesser, Rebecca S., Cos, Paul, Gabrielson, Kathy L., Lazzarino, Giuseppe, Paolocci, Nazareno, Timmermans, Jean-Pierre, Vrints, Christiaan J., Kass, David A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474781/
https://ncbi.nlm.nih.gov/pubmed/18362233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.725481
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