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Spectral Resolution of a Second Binding Site for Nile Red on Cytochrome P450 3A4
Nile Red is sequentially metabolized by Cytochrome P4503A4 to the N-monoethyl and N-desethyl products, which typifies the metabolism of many amine-containing drugs. Sequential metabolism of a single substrate results in complex kinetics that confound predictive models of drug clearance. As a fluores...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474736/ https://ncbi.nlm.nih.gov/pubmed/18395506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.03.017 |
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