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High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation

Mitochondria generate reactive oxygen species, whose downstream lipid peroxidation products, such as 4-hydroxynonenal, induce uncoupling of oxidative phosphorylation by increasing proton leak through mitochondrial inner membrane proteins such as the uncoupling proteins and adenine nucleotide translo...

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Autori principali: Azzu, Vian, Parker, Nadeene, Brand, Martin D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474560/
https://ncbi.nlm.nih.gov/pubmed/18426390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20080321
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