Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

By converting cholesterol to 24S-hydroxycholesterol, cytochrome P450 46A1 (CYP46A1) initiates the major pathway for cholesterol removal from the brain. Two crystal structures of CYP46A1 were determined. First is the 1.9-Å structure of CYP46A1 complexed with a high-affinity substrate cholesterol 3-su...

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Bibliographische Detailangaben
Hauptverfasser: Mast, Natalia, White, Mark Andrew, Bjorkhem, Ingemar, Johnson, Eric F., Stout, C. David, Pikuleva, Irina A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474539/
https://ncbi.nlm.nih.gov/pubmed/18621681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803717105
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