Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

Human cytochrome P450 46A1 (CYP46A1) is one of the key enzymes in cholesterol homeostasis in the brain. The crystallization and heavy-atom structure solution of an active truncated CYP46A1 in complex with the high-affinity substrate analogue cholesterol-3-sulfate (CH-3S) is reported. The 2.6 Å struc...

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Bibliografiska uppgifter
Huvudupphovsmän: White, Mark Andrew, Mast, Natalia, Bjorkhem, Ingemar, Johnson, Eric F., Stout, C. David, Pikuleva, Irina A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2008
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2467524/
https://ncbi.nlm.nih.gov/pubmed/18453684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444908004046
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