The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation

There is no effective treatment for the cardiomyopathy of the most common autosomal recessive ataxia, Friedreich's ataxia (FA). The identification of potentially toxic mitochondrial (MIT) iron (Fe) deposits in FA suggests that Fe plays a role in its pathogenesis. This study used the muscle crea...

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Bibliografische gegevens
Hoofdauteurs: Whitnall, Megan, Rahmanto, Yohan Suryo, Sutak, Robert, Xu, Xiangcong, Becker, Erika M., Mikhael, Marc R., Ponka, Prem, Richardson, Des R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2008
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474513/
https://ncbi.nlm.nih.gov/pubmed/18621680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804261105
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