A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

We have characterized a nontoxic mutant of cholera toxin (CT) as a mucosal adjuvant in mice. The mutant CT was made by substitution of serine with phenylalanine at position 61 of the A subunit (S61F), which resulted in loss of ADP ribosyltransferase activity and toxicity. Mice were intranasally immu...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Yamamoto, Shingo, Kiyono, Hiroshi, Yamamoto, Masafumi, Imaoka, Koichi, Yamamoto, Miho, Fujihashi, Kohtaro, Van Ginkel, Frederik W., Noda, Masatoshi, Takeda, Yoshifumi, McGhee, Jerry R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5267
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