A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

We have characterized a nontoxic mutant of cholera toxin (CT) as a mucosal adjuvant in mice. The mutant CT was made by substitution of serine with phenylalanine at position 61 of the A subunit (S61F), which resulted in loss of ADP ribosyltransferase activity and toxicity. Mice were intranasally immu...

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Detaylı Bibliyografya
Asıl Yazarlar: Yamamoto, Shingo, Kiyono, Hiroshi, Yamamoto, Masafumi, Imaoka, Koichi, Yamamoto, Miho, Fujihashi, Kohtaro, Van Ginkel, Frederik W., Noda, Masatoshi, Takeda, Yoshifumi, McGhee, Jerry R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 1997
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC24667/
https://ncbi.nlm.nih.gov/pubmed/9144226
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