A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity
We have characterized a nontoxic mutant of cholera toxin (CT) as a mucosal adjuvant in mice. The mutant CT was made by substitution of serine with phenylalanine at position 61 of the A subunit (S61F), which resulted in loss of ADP ribosyltransferase activity and toxicity. Mice were intranasally immu...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Proc Natl Acad Sci U S A |
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| Prif Awduron: | , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
National Academy of Sciences
1997
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5267 |
| Tagiau: |
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