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Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules
To understand the functions of SPG6, mutated in the neurodegenerative disease hereditary spastic paraplegia, and of ichthyin, mutated in autosomal recessive congenital ichthyosis, we have studied their Drosophila ortholog, spichthyin (Spict). Spict is found on early endosomes. Loss of Spict leads to...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2464677/ https://ncbi.nlm.nih.gov/pubmed/17220882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1841 |
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