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A simple and robust method for connecting small-molecule drugs using gene-expression signatures
BACKGROUND: Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar pharmacological or toxicological prope...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2464610/ https://ncbi.nlm.nih.gov/pubmed/18518950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-9-258 |
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