Identification of Tumor-initiating Cells in a p53 Null Mouse Model of Breast Cancer

Using a syngeneic p53 null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified by limiting dilution transplantation as well as in vitro mammosphere assay a Lin(−)CD29(H)CD24(H) subpopulation of tumor-initiating cells. Upon subsequent transplantation, this subp...

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Bibliografiske detaljer
Main Authors: Zhang, Mei, Behbod, Fariba, Atkinson, Rachel L., Landis, Melissa D., Kittrell, Frances, Edwards, David, Medina, Daniel, Tsimelzon, Anna, Hilsenbeck, Susan, Green, Jeffrey E., Michalowska, Aleksandra M., Rosen, Jeffrey M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459340/
https://ncbi.nlm.nih.gov/pubmed/18559513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6353
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