A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

Mutational analysis of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) template channel identified two residues, Trp(397) and His(428), which are required for de novo initiation but not for extension from a primer. These two residues interact with the Δ1 loop on the surface of the Rd...

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Main Authors: Chinnaswamy, Sreedhar, Yarbrough, Ian, Palaninathan, Satheesh, Kumar, C. T. Ranjith, Vijayaraghavan, Vinodhini, Demeler, Borries, Lemon, Stanley M., Sacchettini, James C., Kao, C. Cheng
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Transcription, Chromatin, and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459299/
https://ncbi.nlm.nih.gov/pubmed/18442978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801490200
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