Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin.

Plumbagin and shikonin, plant metabolites which have naphthoquinone structures, induced mammalian topoisomerase II-mediated DNA cleavage in vitro. Treatment of a reaction mixture containing these naphthoquinones and topoisomerase II at an elevated temperature (65 degrees C) resulted in a great reduc...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Fujii, N, Yamashita, Y, Arima, Y, Nagashima, M, Nakano, H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245512/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1336338/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.12.2589
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