Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin.
Plumbagin and shikonin, plant metabolites which have naphthoquinone structures, induced mammalian topoisomerase II-mediated DNA cleavage in vitro. Treatment of a reaction mixture containing these naphthoquinones and topoisomerase II at an elevated temperature (65 degrees C) resulted in a great reduc...
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| Gepubliceerd in: | Antimicrob Agents Chemother |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Microbiology (ASM)
1992
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245512/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1336338/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.12.2589 |
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