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Pharmacokinetics and tissue penetration of a single 1,000-milligram, intravenous dose of metronidazole for antibiotic prophylaxis of colorectal surgery.

The levels of metronidazole in serum and tissue penetration of metronidazole were studied after prophylactic administration in 11 patients undergoing elective colorectal surgery. A single dose of 1,000 mg given intravenously was administered before surgery. Adequate drug levels in serum (greater tha...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Martin, C, Sastre, B, Mallet, M N, Bruguerolle, B, Brun, J P, De Micco, P, Gouin, F
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1991
Schlagworte:
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245438/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1810194/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.12.2602
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