In vivo evaluation of NM441, a new thiazeto-quinoline derivative.

NM441 is a lipophilic prodrug of a new thiazeto-quinoline carboxylic acid derivative NM394, and when it is administered orally it is readily absorbed and hydrolyzed to its parent compound. After oral administration of NM441 at a dose of 20 mg/kg to dogs, the peak concentration of NM394 in plasma was...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Ozaki, M, Matsuda, M, Tomii, Y, Kimura, K, Segawa, J, Kitano, M, Kise, M, Shibata, K, Otsuki, M, Nishino, T
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1991
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245419/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1667252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.12.2496
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