In vivo evaluation of NM441, a new thiazeto-quinoline derivative.

NM441 is a lipophilic prodrug of a new thiazeto-quinoline carboxylic acid derivative NM394, and when it is administered orally it is readily absorbed and hydrolyzed to its parent compound. After oral administration of NM441 at a dose of 20 mg/kg to dogs, the peak concentration of NM394 in plasma was...

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Bibliographic Details
Main Authors: Ozaki, M, Matsuda, M, Tomii, Y, Kimura, K, Segawa, J, Kitano, M, Kise, M, Shibata, K, Otsuki, M, Nishino, T
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC245419/
https://ncbi.nlm.nih.gov/pubmed/1667252
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