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MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH(2)-Terminal Kinase and Nuclear Factor-κB Activation in Human Pancreatic Islet Cells
OBJECTIVE—The transcription factor nuclear factor-κB (NF-κB) and the mitogen-activated protein kinases (MAPKs) c-Jun NH(2)-terminal kinase (JNK) 1/2 are known to play decisive roles in cytokine-induced damage of rodent β-cells. The upstream events by which these factors are activated in response to...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Diabetes Association
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2453607/ https://ncbi.nlm.nih.gov/pubmed/18420486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1670 |
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