MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH(2)-Terminal Kinase and Nuclear Factor-κB Activation in Human Pancreatic Islet Cells

OBJECTIVE—The transcription factor nuclear factor-κB (NF-κB) and the mitogen-activated protein kinases (MAPKs) c-Jun NH(2)-terminal kinase (JNK) 1/2 are known to play decisive roles in cytokine-induced damage of rodent β-cells. The upstream events by which these factors are activated in response to...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Mokhtari, Dariush, Myers, Jason W., Welsh, Nils
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Diabetes Association 2008
Ämnen:
Islet Studies
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453607/
https://ncbi.nlm.nih.gov/pubmed/18420486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1670
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