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Estrogen Receptor-α Hinge-Region Lysines 302 and 303 Regulate Receptor Degradation by the Proteasome

Cellular levels of estrogen receptor-α (ERα) protein are regulated primarily by the ubiquitin-proteasome pathway. Dynamic interactions between ERα and the protein degradation machinery facilitate the down-regulation process by targeting receptor lysine residues for polyubiquitination. To date, the l...

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Detalhes bibliográficos
Main Authors: Berry, Nicholas B., Fan, Meiyun, Nephew, Kenneth P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453605/
https://ncbi.nlm.nih.gov/pubmed/18388150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0449
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