The Aryl Hydrocarbon Receptor Mediates Degradation of Estrogen Receptor α through Activation of Proteasomes

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) ligands suppress 17β-estradiol (E)-induced responses in the rodent uterus and mammary tumors and in human breast cancer cells. Treatment of ZR-75, T47D, and MCF-7 human breast cancer cells with TCDD induces proteaso...

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Bibliographische Detailangaben
Hauptverfasser: Wormke, Mark, Stoner, Matthew, Saville, Bradley, Walker, Kelcey, Abdelrahim, Maen, Burghardt, Robert, Safe, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Transcriptional Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC149455/
https://ncbi.nlm.nih.gov/pubmed/12612060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.6.1843-1855.2003
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