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CSN5/Jab1 Is Involved in Ligand-Dependent Degradation of Estrogen Receptor α by the Proteasome
Here, we show that estrogen receptor α (ERα) coimmunoprecipitates with CSN5/Jab1, a subunit of the COP9 signalosome (CSN), and that overexpression of CSN5/Jab1 causes an increase in ligand-induced ERα degradation. Inhibition of either the kinase activity associated with the CSN complex by curcumin o...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1140630/ https://ncbi.nlm.nih.gov/pubmed/15899841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.11.4349-4358.2005 |
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